Saw the thread about the April vial that never turned up and the next shipment not landing til the 4th, shot day on Sunday, no reply from support. The supply frustration is real and I’m not going to pretend it isn’t. But the part that gets lost when people are panicking about a missed shot day is the half-life maths, and once you understand it the gap feels less like a cliff. Tirz runs roughly a 5 day half-life. That’s the number that matters here. It means one missed shot day doesn’t drop your level to zero on Monday. After about 5 days you’re at half of where you were, after 10 days a quarter, and so on. If you normally pin Sunday and the vial turns up the following Thursday, you spent that window coasting down a slow curve, not falling off one. Being 4 days late on a once-weekly is well inside the noise of the schedule. Where a delay actually bites is steady state. It takes 4 to 5 half-lives to build up, so call it 4 to 5 weeks of consistent dosing before your trough levels plateau. A single late pin barely touches that. A two or three week total gap is a different animal, because now you’re letting the accumulated level decay far enough that your appetite signal comes back and you feel like you’ve gone backwards. That’s not the compound failing, that’s just the curve doing what the curve does. So the practical question isn’t “will Sunday ruin everything,” it’s “what’s my actual data across the gap.” And the cheapest proxy any of us has for that is the scale, plus hunger. Not the feeling that you’ve lost momentum, the actual morning number tracked daily. If you weigh through a 10 day delay and the trend line is flat, the gap did nothing measurable and the anxiety was the only thing that moved. If it ticks up 2-3 lb, some of that is water and food volume coming back as appetite returns, not fat regain, and it’ll wash back out once you re-dose. Telling those two apart needs a tracked baseline, not a memory of how you felt last week. One thing I’d separate cleanly: the emotional weight of “are they giving up on me as a customer” is a real and fair thing to sit with, but it’s a different question from “is my level going to crater.” People let the first one drive the panic about the second. The pharmacology says a few days late is fine. If the delay does stretch past a fortnight, the honest move when you restart is to go back to your last tolerated dose rather than assuming you can pick up where you left off, since some of that tolerance has decayed alongside the level. And keep weighing through the whole thing so you’re working from numbers and not from the worry. Hope the vial turns up before Sunday.