i’ve been tracking this temperature dysregulation thing on sema for a bit now, and i’m curious if anyone else has experienced it. for me, it’s been a pretty consistent pattern - days 2-3 post-injection, i’ll feel like i’m running cold, even when everyone around me is warm. white-tipped fingers, needing a hoodie when nobody else is cold, that kind of thing. it’s not every cycle, but often enough that i’ve started to notice it.
i’ve been trying to figure out if it’s related to the suppression curve or something else entirely. has anyone else seen this? i’ve been reading about the rodent studies on central glp-1 agonism and its effect on core temp, and it’s making me wonder if this is a direct central effect rather than something related to fat loss. the fact that it sawtooths with the dosing interval rather than fading steadily over weeks is part of what’s making me think it’s not just a cumulative effect.
anyone have any thoughts on this? i’ve been using the apple watch complication to log my doses and track my food noise, and it’s been helpful to see the patterns emerge - but this temperature thing is still a mystery to me lol
feeling cold when others are warm, i get that. before a migraine attack sometimes i’ll have real bad chills, like a specific cold spot on my upper back no matter how many layers i wear.
cold hands thing too i’ve had that white-tipped fingers issue on sema, not every cycle but enough to notice. you mention “sawtooths with the dosing interval” and that’s kinda what i’ve seen, though i haven’t been tracking it as closely as you.
the central glp-1 agonism effect on core temp is interesting, i’ve read some stuff about that. i log my flares and triggers in careclinic, and the dose reminders are pretty helpful for staying on track.
not sure if it’s related to the temperature dysregulation, but i do notice that my mast cell flares seem to correlate with the injection schedule. has anyone else noticed this temperature thing with sema, or is it just us?
your observation about the ‘sawtooths with the dosing interval’ for temperature dysregulation really tracks with what can happen at Cmax. both suppression and glucose can cause thermoregulation shifts in that window, and it’s not always one or the other. a cgm can help sort which mechanism is louder for you, since those signals can run together. 🤔
that sawtooth pattern makes sense given the half-life. i’ve had similar cold sensitivity, especially when bumping up a dose. logging symptom severity in the app i use showed a tighter correlation with injection day than actual weight loss, and the dark mode charts helped make that clear.