Seven months on sema. Stepped from .5mg to 1mg about six weeks ago. First three weeks: nothing. Ate fine, slept fine, no nausea. Week four I started getting a solid two-hour window of nausea after each shot, some fatigue, and hunger started coming back between shots in a way it hadn’t before. The question I can’t find a clean answer on: is delayed side effect onset actually common, or is this a sign the dose is too high for me specifically? My read - and I’m asking because I’m not sure - is that the first few weeks you’re still riding the previous dose’s tolerance curve, and the real delta from the jump doesn’t land until the drug has fully recalibrated. But I’ve also seen posts where week-four side effects were treated as a signal to hold or step back, not push through. The thing I’m trying to avoid: stepping back to .5 if this is just a normal adjustment window and I lose the ground I was making. Also trying to avoid white-knuckling a dose that’s actually wrong for me and torching my appetite for months. Anyone else hit clean weeks one through three, then get slapped by side effects in week four or later? Did they resolve on their own, or did holding the dose end up being the right call? Curious if there’s a pattern here or if it’s just variable per person.