not a pharmacist, just the tech side. ime when people say reta’s losing effectiveness mid-cycle, it’s almost never the compound. here’s what actually happens: bud (beyond-use date): reconstituted peptides in bac water are typically 30 days from mixing, some pharmacies go 14-21 days to be safe. if you mixed it 4+ weeks ago, you’re likely past expiration depending on yoru pharmacy’s protocol. that changes everything. storage temperature: reta needs consistent 2-8c. if it’s sitting at room temp between injections, degradation starts immediately. “just overnight” adds up fast over 4 weeks. bac water specifically: make sure it’s bac water, not sterile water or saline. the benzyl alcohol is the preservative. injection sites: shallow injects or reusing the same spot creates scar tissue. product’s fine, your tissue just isn’t absorbing as well anymore. stacking reta + tirz is prescriber territory so i won’t go there. but check those 4 first. pretty confident you’ll find it