so i’ve been on plaquenil for like 2 years, ESR and CRP are usually normal at appointments but my C3/C4 keeps dropping right before i flare. idk, rheumatologist said let’s try a biologic, started about 3 weeks ago. the weird thing is my fatigue got worse, not better. i can barely get through work days now, sleeping 11 hours and still feel completely hollow. i know biologics take time (6-8 wks?) but wondering if this is a side effect or if my body’s just being difficult. my rheum said it could be the disease flaring but my joint pain is actually down, which doesn’t track. the fatigue alone is making me feel like i’m failing at normal stuff right now. has anyone else had this? does it level out or did you have to switch?