been on mtx since 2014, and here’s what i figured out: the nausea is just… the drug… it’s not telling you anything about your dose or whether it’s working… i used to think if i was nauseous i needed to go lower, so i kept adjusting down.
turns out my ESR and CRP didn’t care. my rheumatologist finally said straight up - the nausea and the efficacy are separate things. some people barely feel it. some people are wrecked for 24 hours.
neither means the dose is wrong… what matters is your markers improving and your joints feeling better weeks later. i switched to subq to see if it helped, made zero difference… now i just plan around it, eat before the injection, stay home sunday, and accept it’s six hours of garbage.
beats a flare. anyone else been reducing your dose because of the nausea, then realize it made no difference?
anyway.