Through my investigations, I’ve come to the conclusion that many individuals diagnosed with cranial diabetes insipidus, especially idiopathic cases, might have an underlying condition contributing to their symptoms. It’s possible that addressing this underlying issue could resolve their symptoms and potentially even cure the disease.
I’ve encountered numerous cases where diabetes insipidus has gone into remission or disappeared after patients took certain medications for conditions seemingly unrelated to diabetes insipidus. This suggests a potential link between immunosuppressant drugs used for other conditions and the disappearance of diabetes insipidus symptoms. Could it be that, for some individuals, diabetes insipidus is caused by an autoimmune condition? And could medications prescribed for autoimmune issues potentially resolve diabetes insipidus?
In my view, there are individuals with diabetes insipidus stemming from genuine pituitary/hypothalamus issues, such as tumors, inflammation, or head trauma. However, there are also those who have an autoimmune condition that somehow suppresses vasopressin production. Moreover, there may be individuals whose vasopressin production is normal, but their body mistakenly perceives a need for significantly less fluid intake, leading to hypersensitivity to hydration efforts. This condition can cause the body to rapidly expel fluids, despite still producing vasopressin, and the severity of symptoms may fluctuate.