How many punctures before a vial stopper is shot?

Look, I see the posts about finding rubber bits in a vial pop up every few weeks, and the usual advice is sound - use a smaller gauge, don’t punch the same spot, enter at an angle. My question is about what happens after the first time you core it. Three years on TRT, drawing twice a week, so I’ve punctured a lot of stoppers.

Honestly, my concern isn’t the little piece of rubber floating around, it’s the integrity of the seal for the rest of the vial’s life. Once that seal is compromised, are we not opening the door to faster oxidation? Especially for a 10ml vial you’re going to be using for the next 10-12 weeks.

With peptides reconstituted in BAC water, the stability question feels even more critical. I’ve been using a 22g to draw Test Cyp forever without issue, but the stoppers on the last couple of vials have felt softer, less resilient. Cored one last week for the first