Common questions about zero appetite on tirz 5mg, answered straight

anyway, this one comes up every titration bump so let me split it into the part that’s normal and the part that isn’t, because they get mashed together. zero hunger on day 1 of 5mg is expected. the dose stepped up, your gut hasn’t caught up, appetite signaling drops hard for the first few days then usually settles. so one day where you genuinely don’t want food isn’t an alarm. where i’d push back slightly on the framing: “force myself to eat” vs “skip entirely” are the two extremes, and the actual target is neither. you don’t choke down a full plate you don’t want, but a day of literally nothing while you’re physically active (building a greenhouse counts) is a different thing. the issue isn’t the calories so much as protein and electrolytes. lean muscle is what you lose first when intake craters, and on these you’re already at risk for that. so the practical read, not clinical advice: get some protein in even if it’s a shake, and don’t confuse “drinking plenty of fluids” with electrolytes. plain water all day with no food and high activity is how people end up lightheaded and blaming the drug. thing i wouldn’t do is touch the dose over this. one quiet appetite day is not a reason to change anything. where it becomes a doc conversation: if the total no-food days stack up past 2-3, or you get dizzy, heart racing, that’s not something to ride out. bring it to your prescriber with the specifics, how many days, how much you actually got down. “i wasn’t hungry” is vague. “two days, maybe 30g protein total, lightheaded standing up” is useful. ymmv.