seeing a lot of “I’m not at my starting dose anymore so I need to source 15mg” floating around and I want to be pedantic on purpose, bear with me, because the pharmacokinetics here are the whole ballgame and almost nobody tracks them. tirzepatide has a half-life around 5 days. that’s the number that matters. steady state, where what you inject roughly equals what you clear, takes about 4 to 5 half-lives, so call it 3-5 weeks of consistent dosing. that’s the entire reason the titration schedule exists, it isn’t ceremony, it’s giving your GI tract time to meet a rising trough concentration without revolting. so here’s the part people skip: if you’ve been off for months, you are not pharmacologically “at 15mg.” you’ve washed out. five half-lives of zero is roughly 4-5 weeks, and you’ve had way more than that. resuming at 15mg after a long gap is mechanically closer to starting at 15mg than continuing it, which is exactly the dose the titration schedule was built to avoid jumping to cold. I haven’t seen great real-world data on re-escalation after long interruptions specifically (if anyone has a paper, genuinely send it, the trial protocols assume continuous adherence and real life doesn’t). but the PK logic is not subtle. the half-life drift is doing more work than the milligram number on the vial. calibrate the schedule to the washout, not to where you think you “should” be. anyway, that’s one reading, happy to be wrong.