i’m 18 mos post-op shoulder repair, used tirzepatide for 12 wks. dosed 5mg subq, 2x daily, 30 min before meals.
morning dose seemed to crash my blood sugar, so i switched to 1x daily, 10mg, before bed. ROM improved, morning stiffness decreased.
wondering if anyone else has played with tirz timing and seen similar effects
that 5mg twice daily tirzepatide, or even 10mg daily, puts total weekly exposure far above any studied range. this means any observed effect on “blood sugar crash” or “ROM improved” is less about dose timing and more about massive receptor saturation from a supraphysiological dose. you’re likely seeing the gross effects of extreme exposure rather than nuanced timing differences.
That dosing change to avoid a morning glucose crash is a smart move, glad you found a timing that worked. On the ROM and stiffness, I’d distinguish between the primary effect and what might be a secondary one. My read