posting this because most of the timeline updates i read frame the whole thing around weight or A1c and that’s not where the interesting movement happened for me. logging the marker sequence because the order surprised me and i haven’t seen it cleanly named in the personal updates here. baseline, last november: A1c 6.1, fasting glucose 104-108 on waking, fasting insulin 14, trig:HDL 3.2. doctor said “pre-diabetic, we’ll watch it” which is the part that pushed me to start tracking more than the quarterly draw. started compounded tirz in october, currently 7.5mg, been at this dose for about 11 weeks now. what actually moved, in order: weeks 1-4 (2.5mg): fasting glucose dropped first and fast. 104 down to mid-90s within three weeks. nothing else really budged. weight came off but i’m not tracking that closely bc weight is a downstream composite and the snapshot markers tell me more. weeks 5-12 (5mg): trig side of the trig:HDL ratio collapsed. trig went from 142 to 78 by the week 10 draw. HDL barely moved (52 to 54). so the ratio improvement was almost entirely trig-driven at that point. fasting glucose held in the low 90s. weeks 13-20 (7.5mg started week 13): fasting insulin finally moved. 14 to 9.4 at week 16, 6.2 at week 22. this is the one that took longest and it’s also the one i care about most, bc the insulin number is what was hiding behind a “basically fine” A1c for years. weeks 20+: HDL started climbing. 54 to 61 by the most recent draw. so the HDL side came up later and slower than the trig side came down, and i don’t see that sequencing called out in the patient threads, the ratio narrative usually treats both halves as moving together. A1c at month 6: 5.6. but i’d argue the A1c is the least informative number in this stack now bc it integrates 3 months and smooths over exactly the daily variance i was trying to see in the first place. caveats i want to flag: single fasting insulin draws have meaningful variance. the 6.2 is one draw. i’d want to see two more before treating it as the new baseline. asking my doc to repeat it in 4 weeks. weekly cadence means one missed dose is 100% of that week’s exposure. i had one delivery delay in march and the glucose readings the following week were noticeably worse, which is its own data point on how thin the buffer is. the daily check-in habit in careclinic is what made the sequencing visible at all, logging the glucose strip + injection day + symptoms on the same screen meant the trig-first-then-HDL pattern showed up in the export rather than getting lost across three apps. open question for me now is maintenance. not posting about that yet, still working it out.